This series consists of files pertaining to AIDS Services within and across California, funded by the State of California and/or effecting the state as a whole, and materials on specific counties, the state college and university systems, and various health and governmental organizations. This includes legislative bills and statewide budgeting, California ballot initiatives (bills qualified for the ballot by voter signatures instead of legislative acts), Actions by other state organizations and by counties within California. Contents include newspaper clippings, reports, budget materials, legislation and responses, reports and scientific articles.

The majority of statewide materials fall into four subject areas: California Ballot Initiatives (especially Proposition 64 - La Rouche Initiative); the Department of Health Services (DHS), Office of AIDS files; California Legislature files; and State Services Delivery System/Advocacy Groups. The DHS files include a contractor's address list, requests for proposals (RFPs), correspondence, AIDS planning, programs and budget folders, information on alternative tests sites, Medi-Cal costs, and task forces and advisory committees. Also see the "Monthly Field Activities Reports" and the "Quantitative Analysis of AIDS in California." The Legislative files deal the state AIDS budget and AIDS legislation including hearings on various bills. The state delivery system and advocacy group files include files on various local governmental and local health official cooperative associations, the Health Policy and Research Foundation of California, and Lobby for Individual Freedom and Equality (LIFE), as well as the Hemophilia AIDS Project. Of special interest are the index & price list found in the Office of Statewide Health Planning and Development folder and the URSA Institute's "Evaluation of California's AIDS Commission Education Project"

The majority of statewide materials are followed by the county material which is arranged alphabetically by county from Alameda to Sonoma. Not all counties in the state are represented. There is a single folder of material for each of the counties covered, and a folder for the East Bay AIDS Project following the Alameda and Contra Costa County files, since this group covers both of these counties. The county files are followed by files on several California State Medical organizations (such as the California Association of AIDS Agencies (CAAA), the California Medical Association (CMA) and the California Nurses Association (CNA)) and the University of California (Davis, Berkeley, UCLA) [that are not found in Series II: San Francisco City and County].