This series consists of materials related to AIDS services, policy, and information within the city and county of San Francisco. These include both city and county government agencies and community organizations, and the interface between them. Materials include newspaper clippings, scientific articles, correspondence, reports, budgets, statistics, publicity materials, and publications.

Organized roughly alphabetically, the series starts with AIDS Reported Cases (consisting of monthly reports from the San Francisco Department of Public Health) and ends with University of California San Francisco (UCSF) AIDS Activities. The two largest categories in this series are AIDS Service Delivery System and the City and County Agencies and Commissions.

The AIDS Service Delivery System folders are arranged alphabetically by community organizations, and include AIDS/ARC Vigil, Castro Lions Club, Haight Ashbury Free Medical Clinic, Latino AIDS Project, Operation Concern, Project Inform, Project Open Hand, and the Shanti Project, among others. The three largest sets of folders are for the San Francisco AIDS Foundation (SFAF), the Stop AIDS Project, and the Women's AIDS Network (WAN). Three oversize posters have been remove from the Multicultural Prevention Resource Center folder and place in a portfolio folder (P/1) housed with the collection.

The City and County Agencies and Commissions files, which are also arranged roughly alphabetically, include multiple folders covering the San Francisco Health Commission, the Department of Public Health and San Francisco General Hospital, as well as folders on Health Resources and Services Administration AIDS Proposal, HIV Antibody Testing - Alternative Test Sites, Human Rights Commission, and the Public Health Services Hospital. Please note the History of AIDS Service Delivery System and the Epidemiology of AIDS which has subfolders on Intravenous (IV) Drug Use and on Sexually Transmitted Diseases (STDs). One folder of San Francisco General Hospital materials "Utilization Review" has been restricted. The Ward 5A/5B and Ward 86 folders contain press releases, manuals, short reports and newspaper articles.

Other files include AIDS Advisory Groups and Task Forces (includes a folder on the Mayor's Task Force), AIDS Minority Issues, AIDS Perinatal Guidelines, AIDS Planning Activities, and AIDS Research Projects (information on the Association for Women's AIDS Research and Education (AWARE), AIDS School Guidelines and Clinical Study).