This series includes materials from a wide range of departments and offices within the San Francisco AIDS Foundation, as well as "Operations," which is a collection of staff-initiated programs, and finance/budget, grants and contract materials. Included are personnel materials including job descriptions, correspondence, internal memos, statistics, manuals, press releases, meeting minutes, planning and events documents, articles, reports, and more.

This series is divided into 9 subseries: A. Personnel Department; B. Volunteer Services Department; C. Media Services Department; D. "Operations"; E. Development Office; F. Public Policy Office; G. Planning Department; H. Financial Services Department; I. Grants/Contracts Office.