This series documents Lee's work at the Department of Health, Education and Welfare, during the Johnson Administration. He became Deputy Assistant Secretary in August 1965 and was promoted to Assistant Secretary for Health and Science two months later. He left DHEW in February 1969 to become Chancellor of UCSF. This series includes official DHEW correspondence, as well as some of Lee's professional and personal correspondence. It also includes Speeches, Articles and Subject Files. Lee had wide-ranging duties as Assistant Secretary for Health and Science in the Department of Health, Education, and Welfare. The majority of this series consists of Lee's chronological correspondence and shows the sheer daily volume of federal governmental correspondence and a cross-section of the duties of the office. Some routine and repetitive correspondence concerning the issuing of licensing of blood products has been weeded from the collection. There is also correspondence with his friends in California and elsewhere. Major topics included in this series are Family Planning, Medicare, Health Manpower, and the reorganization of the Department of Health Education and Welfare. The series also documents more than 140 speeches made by Lee during his four years at DHEW. Lee also retained many subject files that included numerous government documents and compilations relating to his work at DHEW. These include summaries of legislation, DHEW policy goals and senate briefing booklets. Also included are materials concerning family planning and maternal and child health care issues.